Although torsemide's oral bioavailability and half-life theoretically render it a more efficient diuretic than furosemide, the clinical outcomes of torsemide compared with furosemide remain unclear. We performed a systematic review and meta-analysis, including all published studies that compared torsemide and furosemide use in heart failure patients from January 1996 through August 2019.

Demadex/Torsemide Oral Tab: 5mg, 10mg, 20mg, 100mg. DOSAGE & INDICATIONS. For the treatment of edema. For edema associated with congestive heart failure. Oral dosage. Adults. Initially, 10 to 20 mg PO once daily. If needed, titrate by doubling the dose up to 200 …

The specific loop diuretic dose will be at the discretion of the treating physician with the above noted conversion. Trial enrollment occurs before hospital discharge, at the discretion of the healthcare provider. bumetanide=20 mg torsemide=80 mg furosemide for oral diuretics, and 1 mg bumetanide=20 mg torsemide=40 mg furosemide for intra-venous diuretics. 21,22 The study was approved or determined to qualify for exeption from institutional review board review by the Hospital of the University of Pennsylvania and Yale University Institutional Review Boards. Spironolactone and HCTZ (Aldactazide ®), Torsemide (Demadex ® ).

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Torsemide is closer to 80%. This does allow for a little easier conversion as torsemide is closer to a 1:1 ratio of oral to IV. Furosemide Versus Torsemide: Metabolism Versus Excretion. Furosemide is eliminated from the body, primarily through excretion in the urine. Torsemide undergoes significant hepatic metabolism through CYP2C9.

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